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PGF2 α
(prostarmon f) (5mg/1ml vial)
I. Induction
PGF2A 3000 ug + D5W 500 cc: initial 3 ug/min (0.5 cc = 10 gtt),
+ 5 gtt q 15-30 min
proper dosage at 6-9 ug/min (20-30 gtt/min), max 24 ug/min (80
gtt/min)
end up of 3000 ug:
- bishop score imprved but not in labor, repeat one cycle
- bishop score > 8, repeat one cycle or change to oxytocin after 20-30min
- bishop score not improved, discontinue and repeat the same dosage next day
II. 2nd trimester termination of pregnancy
Extraovulary Foley traction
1. Preparation: 1000 ug + 3.8 ml NS (totally 4ml)
2. Foley catheter no 14-16F with baloon 20-30 ml
Interval (hr) |
0 |
0.5 |
1-1.5 |
1-1.5 |
Q 1-1.5 hr |
Infusion |
250 ug |
750 ug |
1000 ug |
1000 ug |
1000 ug |
|
3.5 ml NS |
3.5 ml NS |
3.5 ml NS |
3.5 ml NS |
3.5 ml NS |
Note:
- no response after first infusion, reinsertion of Foley catheter
- traction of the Foley catheter to occlude the cervical OS
- testing dosage= 250 ug (1ml/1000ug in 3.8 ml NS) + NS 3.5 ml
- the thrid and subsequential dosages were given q one hour (average)
- strong response after testing dosage à
reducing dosage to 500 ug (2ml) or prolonged interval of administration
- max 3000 ug, administration q one hour
III. prophylactic and therapeutic treament of PPH
intravenous administration: same as part I.
Intramyometrial direct injection: 1000 ug (0.2 cc)+ NS 3.8 cc
Prostarmone E (dinoprostone 0.5 mg) oral administration
- administration while OS > 1.5 cm
- interval q one hour, max 6 tablets
- discontinuation after 6 tablets and ineffective, repeat same regimen next
day
Prostaglandin E2 (PGE2) prostin E2
For elective labor induction: one tab to be inserted high into
the posterior fornix, the second tab may be insrted after 6-8 hrs if labor is
not established, continuous administration of the drug for more than 2 days is
not recommed, Max daily dosage 6 mg.
Pinton-S (10 units/1ml 1amp)
1amp in D5W or NS
- IV infusion
- Ordered and recorded in milliunits per minute
- Started at 1-2 milliunits per minute (1-2 gtt) to a maximum of 20
milliunits per minute (20 gtt)
- Cryatalloid solution
Misoprostol: 400-600 μg
vaginally 4 hrs before termination
< 6-7 wks:
Day 1 200 mg or 600 mg mifepristone
Day 3 400 pr 800 μg
misoprostol
Abortion in 4 hours (repeated after 3 hrs if no expulsion
occurs)
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